RNAseq enrichment report
RNAseq enrichment report
- Data info
- Preview section
- Kegg All section
- Kegg Up section
- Kegg Down section
- GO all genes section
- GO BP all genes table
- Bar plot GO BP all genes
- Dotplot GO BP all genes
- GOBarplot GO BP all genes
- Circle-plot GO BP all genes
- GO MF all genes table
- Bar plot GO MF all genes
- Dotplot GO MF all genes
- GOBarplot GO MF all genes
- Circle-plot GO MF all genes
- GO CC all genes table
- Bar plot GO CC all genes
- Dotplot GO CC all genes
- GOBarplot GO CC all genes
- Circle-plot GO CC all genes
- GO up genes section
- GO down genes section
- GO BP down genes table
- Barplot BP Down genes
- Dotplot GO BP down
- GObarplot GO BP down
- Circle plot GO BP down
- GO MF down genes table
- Barplot MF Down genes
- Dotplot GO MF down
- GObarplot GO MF down
- Circle plot GO MF down
- GO CC down genes table
- Barplot CC Down genes
- Dotplot GO CC down
- GObarplot GO CC down
- Circle plot GO CC down
- GSEA section
22 julio 2020
All DE genes
255
Downregulated genes
219
upregulated genes
50
-0.5
Lower logFC cutoff
0.5
Upper logFC cutoff
0.05
P-value cutoff
Data info
| code | name | type | AAV |
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| Astro_GFP_AD_63694 | 63694 | WT | GFP |
| Astro_GFP_WT_63702 | 63702 | WT | GFP |
| Astro_GFP_WT_63703 | 63703 | WT | GFP |
| Astro_GFP_WT_63746 | 63746 | WT | GFP |
| Astro_GFP_WT_63747 | 63747 | WT | GFP |
| Astro_GFP_WT_63765 | 63765 | WT | GFP |
| Astro_GFP_WT_63778 | 63778 | WT | GFP |
| Astro_SOCS3_WT_63704 | 63704 | WT | SOCS3 |
| Astro_SOCS3_WT_63750 | 63750 | WT | SOCS3 |
| Astro_SOCS3_WT_63780 | 63780 | WT | SOCS3 |
Showing 1 to 10 of 12 entries
| GeneName_Ensembl | GeneName_Symbol | Description | baseMean | log2FoldChange | lfcSE | padj |
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| ENSMUSG00000053113 | Socs3 | suppressor of cytokine signaling 3 | 5910.9217 | 3.7792 | 0.2399 | 4.270e-53 |
| ENSMUSG00000073418 | C4b | complement component 4B (Chido blood group) | 9034.4911 | -2.3631 | 0.2002 | 1.183e-29 |
| ENSMUSG00000020932 | Gfap | glial fibrillary acidic protein | 34710.5146 | -1.2885 | 0.1225 | 1.652e-23 |
| ENSMUSG00000062960 | Kdr | kinase insert domain protein receptor | 695.5829 | -3.5915 | 0.397 | 1.803e-17 |
| ENSMUSG00000048163 | Selplg | selectin, platelet (p-selectin) ligand | 2145.4062 | -2.935 | 0.3789 | 8.033e-13 |
| ENSMUSG00000032125 | Robo4 | roundabout guidance receptor 4 | 394.8644 | -2.8263 | 0.3635 | 8.033e-13 |
| ENSMUSG00000071042 | Rasgrp3 | RAS, guanyl releasing protein 3 | 311.4284 | -3.3704 | 0.4375 | 9.550e-13 |
| ENSMUSG00000019929 | Dcn | decorin | 426.5474 | -4.24 | 0.5554 | 1.269e-12 |
| ENSMUSG00000016494 | Cd34 | CD34 antigen | 1048.919 | -2.8907 | 0.3905 | 7.929e-12 |
| ENSMUSG00000038642 | Ctss | cathepsin S | 2909.7405 | -2.7859 | 0.3785 | 9.577e-12 |
Showing 1 to 10 of 255 entries
Preview section
PCA 2D
Box/Violin plot
Top 1 gene
Karyoplot
Volcano plot
MA plot
Kegg All section
Table kegg All genes
| Pathway | N | DEG | p-value | url | |
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| ⊕ | Pertussis | 76 | 9 | 2.317e-6 | mmu05133 |
| ⊕ | Prion diseases | 34 | 6 | 1.160e-5 | mmu05020 |
| ⊕ | AGE-RAGE signaling pathway in diabetic complications | 101 | 9 | 2.450e-5 | mmu04933 |
| ⊕ | Apelin signaling pathway | 137 | 10 | 4.898e-5 | mmu04371 |
| ⊕ | Cell adhesion molecules (CAMs) | 173 | 11 | 7.264e-5 | mmu04514 |
| ⊕ | Complement and coagulation cascades | 92 | 8 | 8.368e-5 | mmu04610 |
| ⊕ | Osteoclast differentiation | 128 | 9 | 1.572e-4 | mmu04380 |
| ⊕ | Leukocyte transendothelial migration | 116 | 8 | 4.187e-4 | mmu04670 |
| ⊕ | Fluid shear stress and atherosclerosis | 147 | 9 | 4.432e-4 | mmu05418 |
| ⊕ | Staphylococcus aureus infection | 122 | 8 | 5.872e-4 | mmu05150 |
Showing 1 to 10 of 49 entries
Chorplot All genes
Dotplot kegg All genes
Heatmap kegg All genes
Netplot kegg All genes
Kegg Up section
Table kegg Up genes
| Pathway | N | DEG | p-value | url | |
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| ⊕ | Prolactin signaling pathway | 73 | 3 | 3.442e-4 | mmu04917 |
| ⊕ | Calcium signaling pathway | 195 | 3 | 5.819e-3 | mmu04020 |
| ⊕ | Gap junction | 86 | 2 | 1.171e-2 | mmu04540 |
| ⊕ | Insulin signaling pathway | 139 | 2 | 2.893e-2 | mmu04910 |
| ⊕ | Ubiquitin mediated proteolysis | 143 | 2 | 3.049e-2 | mmu04120 |
| ⊕ | Spliceosome | 150 | 2 | 3.330e-2 | mmu03040 |
| ⊕ | JAK-STAT signaling pathway | 166 | 2 | 4.007e-2 | mmu04630 |
| ⊕ | Influenza A | 168 | 2 | 4.096e-2 | mmu05164 |
| ⊕ | cGMP-PKG signaling pathway | 173 | 2 | 4.319e-2 | mmu04022 |
Showing 1 to 9 of 9 entries
Chorplot Up genes
Dotplot kegg Up genes
Heatmap kegg Up genes
Netplot kegg Up genes
Kegg Down section
Table kegg Down genes
| Pathway | N | DEG | p-value | url | |
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| ⊕ | Pertussis | 76 | 9 | 7.530e-7 | mmu05133 |
| ⊕ | Prion diseases | 34 | 6 | 5.367e-6 | mmu05020 |
| ⊕ | AGE-RAGE signaling pathway in diabetic complications | 101 | 9 | 8.316e-6 | mmu04933 |
| ⊕ | Apelin signaling pathway | 137 | 10 | 1.535e-5 | mmu04371 |
| ⊕ | Cell adhesion molecules (CAMs) | 173 | 11 | 2.100e-5 | mmu04514 |
| ⊕ | Complement and coagulation cascades | 92 | 8 | 3.224e-5 | mmu04610 |
| ⊕ | MAPK signaling pathway | 294 | 13 | 1.639e-4 | mmu04010 |
| ⊕ | Leukocyte transendothelial migration | 116 | 8 | 1.680e-4 | mmu04670 |
| ⊕ | Staphylococcus aureus infection | 122 | 8 | 2.380e-4 | mmu05150 |
| ⊕ | Osteoclast differentiation | 128 | 8 | 3.304e-4 | mmu04380 |
Showing 1 to 10 of 44 entries
Chorplot Down genes
Dotplot kegg Down genes
Heatmap kegg Down genes
Netplot kegg Down genes
GO all genes section
GO BP all genes table
| Term | Ont | N | DEG | p-value | Ont.level | url | |
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| ⊕ | system development | BP | 4746 | 123 | 7.931e-28 | 3 | GO:0048731 |
| ⊕ | regulation of localization | BP | 2835 | 93 | 4.859e-27 | 2 | GO:0032879 |
| ⊕ | positive regulation of biological process | BP | 6171 | 139 | 2.768e-26 | 1 | GO:0048518 |
| ⊕ | locomotion | BP | 1817 | 73 | 7.641e-26 | 1 | GO:0040011 |
| ⊕ | multicellular organism development | BP | 5362 | 128 | 8.161e-26 | 2 | GO:0007275 |
| ⊕ | anatomical structure development | BP | 5871 | 134 | 1.628e-25 | 2 | GO:0048856 |
| ⊕ | negative regulation of biological process | BP | 5278 | 126 | 2.871e-25 | 1 | GO:0048519 |
| ⊕ | negative regulation of cellular process | BP | 4687 | 118 | 3.272e-25 | 2 | GO:0048523 |
| ⊕ | localization | BP | 5950 | 134 | 6.282e-25 | 1 | GO:0051179 |
| ⊕ | cell proliferation | BP | 1994 | 75 | 7.893e-25 | 1 | GO:0008283 |
Showing 1 to 10 of 2,683 entries
Dotplot GO BP all genes
GOBarplot GO BP all genes
Circle-plot GO BP all genes
GO MF all genes table
| Term | Ont | N | DEG | p-value | Ont.level | url | |
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| ⊕ | protein binding | MF | 9006 | 170 | 8.507e-26 | 2 | GO:0005515 |
| ⊕ | binding | MF | 13357 | 200 | 7.939e-20 | 1 | GO:0005488 |
| ⊕ | signaling receptor binding | MF | 1770 | 50 | 1.477e-11 | 3 | GO:0005102 |
| ⊕ | integrin binding | MF | 128 | 14 | 4.119e-11 | 3 | GO:0005178 |
| ⊕ | cell adhesion molecule binding | MF | 241 | 18 | 4.219e-11 | 3 | GO:0050839 |
| ⊕ | protein-containing complex binding | MF | 1249 | 40 | 5.808e-11 | 2 | GO:0044877 |
| ⊕ | extracellular matrix binding | MF | 59 | 9 | 6.763e-9 | 2 | GO:0050840 |
| ⊕ | enzyme binding | MF | 2313 | 51 | 4.538e-8 | 3 | GO:0019899 |
| ⊕ | cytokine binding | MF | 129 | 11 | 7.209e-8 | 3 | GO:0019955 |
| ⊕ | identical protein binding | MF | 1887 | 44 | 9.762e-8 | 3 | GO:0042802 |
Showing 1 to 10 of 292 entries
Dotplot GO MF all genes
GOBarplot GO MF all genes
Circle-plot GO MF all genes
GO CC all genes table
| Term | Ont | N | DEG | p-value | Ont.level | url | |
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| ⊕ | cell periphery | CC | 5488 | 122 | 2.104e-21 | 2 | GO:0071944 |
| ⊕ | plasma membrane | CC | 5343 | 119 | 8.918e-21 | 2 | GO:0005886 |
| ⊕ | cell part | CC | 16277 | 220 | 1.902e-18 | 1 | GO:0044464 |
| ⊕ | cell | CC | 16281 | 220 | 1.986e-18 | 1 | GO:0005623 |
| ⊕ | cell surface | CC | 1095 | 46 | 8.351e-17 | 2 | GO:0009986 |
| ⊕ | plasma membrane part | CC | 2996 | 77 | 1.070e-15 | 2 | GO:0044459 |
| ⊕ | membrane | CC | 9429 | 149 | 5.913e-13 | 1 | GO:0016020 |
| ⊕ | apical part of cell | CC | 416 | 24 | 5.510e-12 | 2 | GO:0045177 |
| ⊕ | side of membrane | CC | 760 | 32 | 6.383e-12 | 2 | GO:0098552 |
| ⊕ | membrane part | CC | 7379 | 124 | 8.610e-12 | 1 | GO:0044425 |
Showing 1 to 10 of 212 entries
Dotplot GO CC all genes
GOBarplot GO CC all genes
Circle-plot GO CC all genes
GO up genes section
GO BP up genes table
| Term | Ont | N | DEG | p-value | Ont.level | url | |
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| ⊕ | negative regulation of biological process | BP | 5278 | 19 | 1.996e-7 | 1 | GO:0048519 |
| ⊕ | system development | BP | 4746 | 18 | 2.679e-7 | 3 | GO:0048731 |
| ⊕ | regulation of metabolic process | BP | 5953 | 19 | 1.460e-6 | 2 | GO:0019222 |
| ⊕ | negative regulation of cellular process | BP | 4687 | 17 | 1.552e-6 | 2 | GO:0048523 |
| ⊕ | multicellular organism development | BP | 5362 | 18 | 1.800e-6 | 2 | GO:0007275 |
| ⊕ | intracellular signal transduction | BP | 2608 | 13 | 1.829e-6 | 3 | GO:0035556 |
| ⊕ | regulation of cellular metabolic process | BP | 5401 | 18 | 2.013e-6 | 3 | GO:0031323 |
| ⊕ | regulation of signal transduction | BP | 2780 | 13 | 3.771e-6 | 3 | GO:0009966 |
| ⊕ | anatomical structure development | BP | 5871 | 18 | 7.189e-6 | 2 | GO:0048856 |
| ⊕ | regulation of primary metabolic process | BP | 5248 | 17 | 7.940e-6 | 3 | GO:0080090 |
Showing 1 to 10 of 872 entries
Dotplot GO BP up
GObarplot GO BP up
Circle plot GO BP up
GO MF up genes table
| Term | Ont | N | DEG | p-value | Ont.level | url | |
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| ⊕ | binding | MF | 13357 | 25 | 9.947e-5 | 1 | GO:0005488 |
| ⊕ | SH2 domain binding | MF | 39 | 2 | 9.164e-4 | 4 | GO:0042169 |
| ⊕ | beta1-adrenergic receptor activity | MF | 1 | 1 | 1.147e-3 | 8 | GO:0004940 |
| ⊕ | luteinizing hormone receptor activity | MF | 1 | 1 | 1.147e-3 | 4 | GO:0004964 |
| ⊕ | choriogonadotropin hormone receptor activity | MF | 1 | 1 | 1.147e-3 | 4 | GO:0035472 |
| ⊕ | choriogonadotropin hormone binding | MF | 1 | 1 | 1.147e-3 | 3 | GO:0038106 |
| ⊕ | ganglioside GM2 binding | MF | 1 | 1 | 1.147e-3 | 5 | GO:1905574 |
| ⊕ | ganglioside GM3 binding | MF | 1 | 1 | 1.147e-3 | 5 | GO:1905575 |
| ⊕ | ganglioside GP1c binding | MF | 1 | 1 | 1.147e-3 | 5 | GO:1905577 |
| ⊕ | ion binding | MF | 5441 | 14 | 1.177e-3 | 2 | GO:0043167 |
Showing 1 to 10 of 101 entries
Dotplot GO MF up
GObarplot GO MF up
Circle plot GO MF up
GO CC up genes table
| Term | Ont | N | DEG | p-value | Ont.level | url | |
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| ⊕ | intracellular membrane-bounded organelle | CC | 10292 | 21 | 4.364e-4 | 3 | GO:0043231 |
| ⊕ | cytoplasmic vesicle | CC | 1811 | 8 | 7.330e-4 | 4 | GO:0031410 |
| ⊕ | intracellular vesicle | CC | 1816 | 8 | 7.465e-4 | 3 | GO:0097708 |
| ⊕ | vesicle | CC | 1948 | 8 | 1.184e-3 | 3 | GO:0031982 |
| ⊕ | cell part | CC | 16277 | 26 | 1.293e-3 | 1 | GO:0044464 |
| ⊕ | cell | CC | 16281 | 26 | 1.301e-3 | 1 | GO:0005623 |
| ⊕ | membrane-bounded organelle | CC | 11019 | 21 | 1.310e-3 | 2 | GO:0043227 |
| ⊕ | endomembrane system | CC | 3758 | 11 | 1.908e-3 | 2 | GO:0012505 |
| ⊕ | organelle | CC | 12303 | 22 | 2.122e-3 | 1 | GO:0043226 |
| ⊕ | CNTFR-CLCF1 complex | CC | 3 | 1 | 3.438e-3 | 2 | GO:0097059 |
Showing 1 to 10 of 66 entries
Dotplot GO CC up
GObarplot GO CC up
Circle plot GO CC up
GO down genes section
GO BP down genes table
| Term | Ont | N | DEG | p-value | Ont.level | url | |
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| ⊕ | regulation of localization | BP | 2835 | 83 | 1.423e-24 | 2 | GO:0032879 |
| ⊕ | locomotion | BP | 1817 | 66 | 4.472e-24 | 1 | GO:0040011 |
| ⊕ | positive regulation of biological process | BP | 6171 | 122 | 7.947e-23 | 1 | GO:0048518 |
| ⊕ | cell proliferation | BP | 1994 | 67 | 1.391e-22 | 1 | GO:0008283 |
| ⊕ | cell motility | BP | 1595 | 60 | 1.627e-22 | 2 | GO:0048870 |
| ⊕ | localization of cell | BP | 1595 | 60 | 1.627e-22 | 2 | GO:0051674 |
| ⊕ | system development | BP | 4746 | 105 | 2.134e-22 | 3 | GO:0048731 |
| ⊕ | regulation of cellular component movement | BP | 1028 | 48 | 9.724e-22 | 3 | GO:0051270 |
| ⊕ | regulation of cell motility | BP | 939 | 46 | 1.150e-21 | 3 | GO:2000145 |
| ⊕ | movement of cell or subcellular component | BP | 2014 | 66 | 1.244e-21 | 2 | GO:0006928 |
Showing 1 to 10 of 2,384 entries
Dotplot GO BP down
GObarplot GO BP down
Circle plot GO BP down
GO MF down genes table
| Term | Ont | N | DEG | p-value | Ont.level | url | |
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| ⊕ | protein binding | MF | 9006 | 154 | 3.169e-25 | 2 | GO:0005515 |
| ⊕ | binding | MF | 13357 | 175 | 1.412e-16 | 1 | GO:0005488 |
| ⊕ | signaling receptor binding | MF | 1770 | 44 | 2.914e-10 | 3 | GO:0005102 |
| ⊕ | protein-containing complex binding | MF | 1249 | 36 | 3.225e-10 | 2 | GO:0044877 |
| ⊕ | cell adhesion molecule binding | MF | 241 | 16 | 4.898e-10 | 3 | GO:0050839 |
| ⊕ | integrin binding | MF | 128 | 12 | 1.557e-9 | 3 | GO:0005178 |
| ⊕ | extracellular matrix binding | MF | 59 | 8 | 4.805e-8 | 2 | GO:0050840 |
| ⊕ | cytoskeletal protein binding | MF | 970 | 27 | 1.349e-7 | 3 | GO:0008092 |
| ⊕ | identical protein binding | MF | 1887 | 40 | 1.743e-7 | 3 | GO:0042802 |
| ⊕ | cytokine binding | MF | 129 | 10 | 2.257e-7 | 3 | GO:0019955 |
Showing 1 to 10 of 256 entries
Dotplot GO MF down
GObarplot GO MF down
Circle plot GO MF down
GO CC down genes table
| Term | Ont | N | DEG | p-value | Ont.level | url | |
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| ⊕ | cell periphery | CC | 5488 | 112 | 2.113e-21 | 2 | GO:0071944 |
| ⊕ | plasma membrane | CC | 5343 | 110 | 3.360e-21 | 2 | GO:0005886 |
| ⊕ | cell surface | CC | 1095 | 44 | 1.845e-17 | 2 | GO:0009986 |
| ⊕ | plasma membrane part | CC | 2996 | 72 | 3.463e-16 | 2 | GO:0044459 |
| ⊕ | cell part | CC | 16277 | 194 | 4.872e-16 | 1 | GO:0044464 |
| ⊕ | cell | CC | 16281 | 194 | 5.060e-16 | 1 | GO:0005623 |
| ⊕ | membrane | CC | 9429 | 135 | 5.722e-13 | 1 | GO:0016020 |
| ⊕ | apical part of cell | CC | 416 | 23 | 2.936e-12 | 2 | GO:0045177 |
| ⊕ | membrane part | CC | 7379 | 112 | 1.626e-11 | 1 | GO:0044425 |
| ⊕ | side of membrane | CC | 760 | 29 | 3.454e-11 | 2 | GO:0098552 |
Showing 1 to 10 of 199 entries
Dotplot GO CC down
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GSEA section
GSEA table results
| Description | setSize | enrichmentScore | NES | pvalue | p.adjust | qvalues | rank |
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| mmu04010_MAPK signaling pathway | 245 | -0.7561 | -1.5734 | 0.001 | 0.0279 | 0.0244 | 409 |
| mmu04151_PI3K-Akt signaling pathway | 263 | -0.7212 | -1.5046 | 0.001 | 0.0279 | 0.0244 | 688 |
| mmu05202_Transcriptional misregulation in cancer | 135 | -0.7486 | -1.5247 | 0.0011 | 0.0279 | 0.0244 | 792 |
| mmu04060_Cytokine-cytokine receptor interaction | 126 | -0.7745 | -1.5685 | 0.0011 | 0.0279 | 0.0244 | 902 |
| mmu04371_Apelin signaling pathway | 103 | -0.7943 | -1.6001 | 0.0011 | 0.0279 | 0.0244 | 601 |
| mmu04514_Cell adhesion molecules (CAMs) | 89 | -0.8516 | -1.6898 | 0.0012 | 0.0279 | 0.0244 | 411 |
| mmu04670_Leukocyte transendothelial migration | 86 | -0.8061 | -1.597 | 0.0012 | 0.0279 | 0.0244 | 443 |
| mmu05322_Systemic lupus erythematosus | 72 | -0.8647 | -1.6855 | 0.0012 | 0.0279 | 0.0244 | 246 |
| mmu04650_Natural killer cell mediated cytotoxicity | 70 | -0.8205 | -1.593 | 0.0012 | 0.0279 | 0.0244 | 411 |
| mmu04512_ECM-receptor interaction | 67 | -0.8586 | -1.6651 | 0.0012 | 0.0279 | 0.0244 | 49 |
Showing 1 to 10 of 17 entries
GSEA plot
